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Nano-Micro Letters

Copper-Based Targeted Nanocatalytic Therapeutics for Non-Small CellLung Cancer

Copper‑Based Targeted Nanocatalytic Therapeuticsfor Non‑Small Cell Lung Cancer

ABSTRACT Conventional treatments for non-small cell lung cancer(NSCLC) sufer from low remission rates, high drug resistance, and severeadverse efects.

Remodeling the immunosuppressive microenvironment of KARS-LKB1 co-mutant non-small cell lung cancer via targeted PGAM5 siRNA delivery for enhanced immunotherapy☆

KRAS–LKB1 (KL) co-mutant non-small cell lung cancer (NSCLC) is characterized by an immunologically “cold” tumor immune microenvironment (TIME), and resultantly exhibits intrinsic resistance to immune checkpoint inhibitor (ICI) therapy.

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